Collect. Czech. Chem. Commun.
1994, 59, 2481-2492
https://doi.org/10.1135/cccc19942481
One-Step Synthesis of 2-Amino-3-furancarboxylic Acid Derivatives from 2-Furancarbaldehyde
Peter Šafářa, Pavel Čepecb, František Považaneca, Anna Koreňováa and Naďa Prónayovác
a Department of Organic Chemistry, Slovak Technical University, 812 37 Bratislava, Slovak Republic
b Wood Research Institute, 841 05 Bratislava, Slovak Republic
c Central Laboratory, Slovak Technical University, 812 37 Bratislava, Slovak Republic
Abstract
Reaction of derivatives of 2-furancarbaldehyde or 2-acetylfuran with malononitrile, methyl cyanoacetate or cyanoacetamide in the presence of secondary amines afforded derivatives of 2-amino-3-furancarboxylic acid in 45 - 88% yields.
