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Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

Abdel-Alim M. Abdel-Alima, Abdel-Nasser A. El-Shorbagia, Mahmoud A. El-Gendya and Hosny A. H. El-Shareifb

a Pharmaceutical Chemistry Department, Assiut University, Assiut, Egypt
b Pharmaceutical Chemistry Department, Al-Azhar University, Assiut, Egypt


2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.