Collect. Czech. Chem. Commun. 1993, 58, 1944-1952

Synthesis of Some New Spirothiazolidinones Incorporated with Quinazoline Moiety

Zeinab A. Hoziena, Abd El-Hamid N. Ahmedb and Maher F. El-Zohrya

a Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt
b Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71516, Egypt


In continuation of our previous work, together with the importance of the combination of spirothiazolidinones with quinazoline moieties, this work reports the synthesis of some new spirothiazolidinones incorporated with quinazoline moiety. Our precursors, 2-spiro-1,3-oxathiolan-5-ones IIIa - IIIe were prepared according to our previously reported method, starting with appropriate cyclic ketones.