Collect. Czech. Chem. Commun. 1993, 58, 1919-1924

The Isolation of Carnosic Acid 12-Methyl Ether from Salvia officinalis L. and NMR Study of Its Methyl Ester

Zoltan Djarmatia, Ratko M. Jankovb, János Csanádic and Aleksandar Djordjevicd

a Technical High School and Institute of Technology "Servo Mihalj", 23000 Zrenjanin, Yugoslavia
b Department of Biochemistry, Faculty of Science, 11000 Belgrade, Yugoslavia
c Institute of Chemistry, Faculty of Science, 21000 Novi Sad, Yugoslavia
d Institute of Technology "Servo Mihalj", 23000 Zrenjanin, Yugoslavia


In continuation of our studies on the chemical compositions of the aerial parts of cultivated Salvia officinalis L., we have isolated the title substance for the first time in this type of Sage. The structure of this isolated compound was established by spectroscopic data and some chemical reactions. Investigation of 1H and 13C NMR, homonuclear (COSY) (1H-1H), heteronuclear (HETCOR) (1H-13C), and selective INEPT spectra, permitted the unambiguous assignment of the 1H and 13C NMR spectra, what gave the possibility to resolve signals of similar natural products.