Collect. Czech. Chem. Commun. 1993, 58, 996-1000

Characterization of the Hydrophobic Properties of Amino Acids. II. How Hydrophobic, Hydrophilic and Lipophilic Is Tryptophan?

Josef Chmelík

Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, 611 42 Brno, Czech Republic


The model for the characterization of hydrophobicity, hydrophilicity and lipophilicity of compounds is presented. It is based on the vapour-to-solvent coefficients for hydrophilicity and lipophilicity and the partition coefficient for hydrophobicity. It is shown that some apparently contradictory facts can be understood on the basis of this model.