Collect. Czech. Chem. Commun. 1993, 58, 310-314

Dependence of log k Obtained by HPLC on log P'exp in the Series Piperidino and Morpholinoethyl Esters of o-, m- and p-Alkoxy Substituted Phenylcarbamic Acids

Eva Sedlárováa, Jozef Čižmárika, Dana Novosedlíkováa, Katarína Podhorováa, Lucia Šrankováb and Andrej Šrankb

a Department of Pharmaceutical Chemistry, Comenius University, 832 32 Bratislava, Slovak Republic
b Slovakofarma, 920 27 Hlohovec, Slovak Republic


Dependence of log k obtained by the HPLC method on log P'exp obtained by the classical method was investigated in two series of basic ethyl phenylcarbamic acids. The linear dependence was found with o-substituted series and p-substituted morpholino derivatives. The relation with p-derivatives of the piperidino series is close to linearity, while that of m-derivatives of both series is not linear.