Collect. Czech. Chem. Commun. 1993, 58, 197-204

Antimycobacterial 2-Arylamino-2-Thioxoacetamides

Karel Waissera, Miloš Macháčeka, Želmíra Odlerováb, Wilfried Thielc and Roland Mayerd

a Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, 501 65 Hradec Králové, Czech Republic
b Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovak Republic
c Arzneimittelwerk Dresden GmbH, D(O)-8122 Radebeul, Germany
d Institut für Organische Chemie und Farbstoffchemie, Technische Universität Dresden, D(O)-8027 Dresden, Germany


A series of 13 2-arylamino-2-thioxoacetamides was tested against Mycobacterium tuberculosis and M. kansasii. Structure-activity relationships were analyzed quantitatively using the Free-Wilson method. Evaluation of the antimycobacterial profile with regard to equipotency of both activities was accomplished by means of a recently proposed method for evaluation of activity profile with respect to intended therapeutical use.