Collect. Czech. Chem. Commun. 1992, 57, 1693-1698

Synthesis of 2-Alkyl-1-allyl-3-arylsulfonyl-isothioureas

Martin Hansa, Helmut Reinkea, Thomas Schöffmanna, Heinz Dehnea and Bernhard Olkb

a Institute of Chemistry, Rostock University, O-2600 Gustrow, Germany
b Institute for Isotope and Radiation Research, O-7000 Leipzig, Germany


2-Alkyl-1-allyl-3-arylsulfonyl-isothioureas III are not described in the literature. These compounds are valuable intermediate products for new potentially bioactive sulfonamide derivatives. The title compounds III can be prepared from 1-allyl-3-arylsulfonyl-thioureas I with monohalogen alkanes under alkaline conditions (method A) or from N-arylsulfonyl-iminothiocarbonic acid ester chlorides II with excess allylamine (method B).