Collect. Czech. Chem. Commun. 1992, 57, 1483-1486

Simple Preparation of Methyl 4-Chloromethyl- and Methyl 5-Chloromethyl-2-thiophenecarboxylate

Václav Kozmík and Jaroslav Paleček

Institute of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6


Selective reduction of a mixture of methyl 4-chloromethyl-2-thiophenecarboxylate (I) and the 5-chloromethyl isomer II, prepared by chloromethylation of methyl 2-thiophenecarboxylate (III), gave pure 4-chloromethyl derivative I and 5-methyl-2-thiophenecarboxylate (V) which on treatment with sulfuryl chloride was converted into the 5-chloromethyl isomer II.