Collect. Czech. Chem. Commun. 1992, 57, 1134-1142

The Antifungal Activity of Some Aliphatic and Aromatic Acids

Bohuslav Ritticha, Marta Pirochtováa, Jiří Hřiba, Kamila Jurtíkováb and Petr Doležalc

a Institute of Systematic and Ecological Biology, 603 65 Brno
b Research Institute of Soil Improvement, 602 00 Brno
c University of Agriculture, 613 00 Brno


The present paper deals with the relationship between biological activities of some aliphatic and aromatic acids and their physico-chemical parameters expressing the influence of hydrophobic factors. The test strain in the biotest of growth inhibition was the fungus Fusarium moniliforme CCMF-180 and Penicillium expansum CCMF-576. Significant relationship between antifungal activities of un-ionized form of aliphatic acids and their capacity factors (log k'0) extrapolated to pure water, partition coefficients determined in 1-octanol-water system (log Poct) and the first order of molecular connectivity indices (1χ) were calculated. The ionized form of aliphatic acids were antifungally active too. For benzoic acids significant relationships between antifungal activities and capacity factors of anionic form (log k'ia) were calculated.