Collect. Czech. Chem. Commun. 1992, 57, 1081-1084

Synthesis of 5,7-Dioxo-6-halogenophenyl-6,7-dihydro-5H-dibenzo[a,c]cycloheptene Derivatives

Hinyu N. Nedeva, Neiko M. Stoyanovb, Stoyan Mincheva and Boris V. Aleksievc

a Department of Chemistry, University of Shumen, 9700 Shumen, Bulgaria
b Department of Chemistry, Institute of Biotechnology, 7200 Razgrad, Bulgaria
c Department of Organic Chemistry, Higher Institute of Chemical Technology, 1126 Sofia, Bulgaria


The condensation of diphenic anhydride with o-, m- and p- halogenosubstituted phenylacetic acids gave the respective enolacetates Ia-Ie. The alkaline hydrolysis of these compounds yields the diketones IIa-IIe. After testing blood cloting agents in vivo, the last compounds showed indications of anticoagulants.