Collect. Czech. Chem. Commun. 1992, 57, 123-133

Cyclization Reactions of 2-(6-Azauracil-5-yl)benzoic Acid and Some Its Derivatives

Miloslav Hejseka, Jan Sloukaa, Vojtěch Bekáreka and Antonín Lyčkab

a Department of Analytical and Organic Chemistry, Palacký University, 771 46 Olomouc
b Research Institute of Organic Syntheses, 532 18 Pardubice-Rybitví


2-(6-Azauracil-5-yl)benzoic acid (Ib) and its thio analogue Ia give new heterocyclic compounds, 1,2-dihydro-1,2,4-triazino[5,6-c]isocoumarin-3-one (IVb) and analogous 3-thione IVa, respectively, on treatment with N,N'-dicyclohexylcarbodiimide. A series of substituted 1,2,4-triazino[5,6-c]isoquinolines V-XVI have been prepared from these compounds and from other functional derivatives (II, III) of the acids I.