Collect. Czech. Chem. Commun. 1992, 57, 33-45

Theoretical Interpretation of High-Performance Chromatographic Data for a Heterogeneous Series of Compounds

Vladimír Jakuš

Department of Organic Technology, Slovak Technical University, Detached Laboratory in the Research Institute for Petrochemistry, 971 04 Prievidza


A new approach to theoretical evaluation of the Gibbs free energy of solvation was applied for estimation of retention data in high-performance liquid chromatography on reversed phases (RP-HPLC). Simple and improved models of stationary and mobile phases in RP-HPLC were employed. Statistically significant correlations between the calculated and experimental data were obtained for a heterogeneous series of twelve compounds.