Collect. Czech. Chem. Commun. 1991, 56, 1944-1947

Palladium-catalyzed cross-coupling reaction of organostannanes with nucleoside halides

Mohamed Ezeldin Hassan

Chemistry Department, Faculty of Science, The African University, Aswan, Egypt


A general reaction is described for the synthesis of C-5 substituted nucleosides through the coupling of organostannanes with nucleoside-palladium intermediate derived in situ from 5-iodouridine (or 5-iodo-2’-deoxyuridine) and [PdCl2(PPh3)2]. The reaction was used for the synthesis of C-5 aryl, heteroaryl, vinyl, allyl and alkyl substituted nucleosides.