Collect. Czech. Chem. Commun.
1991, 56, 1944-1947
https://doi.org/10.1135/cccc19911944
Palladium-catalyzed cross-coupling reaction of organostannanes with nucleoside halides
Mohamed Ezeldin Hassan
Chemistry Department, Faculty of Science, The African University, Aswan, Egypt
Abstract
A general reaction is described for the synthesis of C-5 substituted nucleosides through the coupling of organostannanes with nucleoside-palladium intermediate derived in situ from 5-iodouridine (or 5-iodo-2’-deoxyuridine) and [PdCl2(PPh3)2]. The reaction was used for the synthesis of C-5 aryl, heteroaryl, vinyl, allyl and alkyl substituted nucleosides.
