Collect. Czech. Chem. Commun. 1991, 56, 1489-1494

Synthesis of some new sulfonamide derivatives of 7-chloroquinoline-5,8-dione and pyridocarbazolediones

Amal S. Yannia, Zarif H. Khalila and Ahmed A. Timmawyb

a Chemistry Department, Faculty of Science, Assiut University, Egypt
b Bacteriology Department, Faculty of Medicine, Assiut University, Egypt


Interaction of 6-chloroquinoline-5,8-dione hydrochloride (I) or 6,7-dichloroquinoline-5,8-dione (II) with sulfa drug in ethanol containing diethylaniline afforded 7-substituted sulfonamide-10H-pyrido[3,2-b]carbazole-5,11-dione (III), and sulfonamide derivatives of 7-chloroquinoline-5,8-diones (IV). Moreover the reaction of II with arylamine in pyridine afforded substituted 6H-pyrido[2,3-b]carbazole-5,11-dione (V). The structure of the compounds was determined by elemental and spectral analysis, and by chemical reaction.