Collect. Czech. Chem. Commun. 1991, 56, 1147-1150

Horseradish peroxidase-mediated preparation of dimers from eugenol and isoeugenol

Andrzej R. Krawczyk, Ewa Lipkowska and Jerzy T. Wróbel

Department of Chemistry, Warsaw University, 1 L. Pasteur’ St. 02093 Warsaw, Poland


Coupling of eugenol (I) and isoeugenol (II) by means of horseradish peroxidase and hydrogen peroxide resulted in ~20% yield of dimeric compounds: 5,5’-diallyl-2,2’-dihydroxy-3,3’-dimethoxy-biphenyl (III) and 2-(4’-hydroxy-3’-methoxy)phenyl-7-methoxy-3-methyl-5-propenyl-2,3-dihydrobenzofurane (IV), respectively.