Collect. Czech. Chem. Commun. 1991, 56, 1110-1115

Synthesis of polysubstituted 2,4-dimethylquinolines as potential antimalarial drugs

Stoyan Parusheva, Yoncho Vlahova, Radoslav Vlahova, Peter Nickelb and Günther Snatzkec

a Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
b Pharmaceutical Institute, University of Bonn, D-5300, F.R.G.
c Ruhr University Bochum, D-4630 Bochum, F.R.G.


A synthetic way for obtaining 6-amino-2,4-dimethylquinoline derivatives from 2,5-dichloraniline by successive ring closure, nitration, aromatic substitution at so activated quinoline ring, followed by reduction of the nitro group to amino group and alkylation of the last is described.