Collect. Czech. Chem. Commun. 1991, 56, 1019-1031

Reactivity of triformylmethane. I. Reactions of triformylmethane with selected types of amino compounds

Zdeněk Arnold, Miloš Buděšínský and Magdalena Pánková

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Reactions of triformylmethane with various types of amino compounds were investigated. Besides with ammonia, triformylmethane reacts spontaneously with primary amines, aminoacids and their esters, urea and related compounds including carbamic acid derivatives. Reactions with amides of carboxylic and sulfonic acids require catalysis with Lewis acids. Primary products are aminomethylenemalonaldehyde derivatives IIIa-IIIv. Reactions of triformylmethane with excess of selected primary amines and two secondary amines (dimethylamine and morpholine) were also studied.