Collect. Czech. Chem. Commun. 1991, 56, 685-694

Reactions of isothiocyanates and isocyanates with some silylated nitrogen-containing nucleophiles

Jozef Gonda and Zuzana Antalová

Department of Organic Chemistry, Faculty of Natural Sciences, P. J. Šafárik University, 041 67 Košice


Aryl isothiocyanates and arylisocyanates react with N,O-bis(trimethylsilyl)acetamide to give N-methyl-N’-arylthioureas and ureas. Also nucleophilic additions of other aprotic nucleophiles (e.g. N-trimethylsilylimidazole, N-trimethylsilylpiperidine and N-trimethylsilylmorpholine) to the N=C=X (X = O, S) group were investigated.