Collect. Czech. Chem. Commun.
1991, 56, 2892-2905
https://doi.org/10.1135/cccc19912892
The synthesis of 5-methyl-19-nor-5β-pregna-9,16-diene-3,20-dione, 5-methyl-19-nor-5β-pregna-9,10-diene-3,6,20-trione and their analogues with annellated E ring
Jiří Polman and Alexander Kasal
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
The synthesis of compounds VII, XVII, XXXIV and XXXVII is described, in which biological activity is assumed. The key steps of their preparation are the dehalogenation of compound XVIII and radicalic deoxygenation of the 6β-hydroxy group in compound XXX, which take place without skeletal rearrangements.
