Collect. Czech. Chem. Commun. 1991, 56, 2494-2499

Reaction of 4-aroyl-2(3H)-dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids

Maria M. Curzua, Gérard A. Pinnaa, Giorgio Cignarellab, Daniela Barloccob and Maria Piera Demontisc

a Istituto Chimica Farmaceutica, Università di Sassari, Via Muroni 23, 07 100 Sassari, Italy
b Istituto Chimica Farmaceutica e Tossicologica, Università di Milano, Viale Abruzzi 42, 20131 Milano, Italy
c Istituto Farmacologia, Facoltà di Medicina e Chirurgia, Università di Sassari, 07 100 Sassari, Italy


We have synthesized and tested for their antiinflammatory activity a new series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids (IVa-IVg). Preliminary pharmacological results seem to indicate the 3-phenyl derivative IVa as the most interesting compound. In fact, when tested against carrageenin edema in Wistar rats, it shows antiinflammatory activity comparable to that of naproxene, taken as reference drug, though of shorter duration. All the substituted phenyl derivatives were less active (IVd-IVf) or inactive (IVb, IVc, IVg).