Collect. Czech. Chem. Commun. 1991, 56, 2288-2297

Fused imidazo-, pyrimido- and 1,3-diazepino[1,2-c]pteridines from o-aminopyrazinecarbonitriles

Walter Ried* and Thomas Russ

Institut für Organische Chemie der Universität Frankfurt am Main, Laboratorium Niederrad, Theodor-Stern-Kai 7, D-6000 Frankfurt a.M. 70, F.R.G.


A series of partially hydrogenated imidazo[1,2-c]pteridines IXa – IXc, XIa - XIf and XVa - XVc, pyrimidol[1,2-c]pteridines XIIa - XIId and XVIa - XVIc, and 1,3-diazepinol[1,2-c]pteridines XIIIa - XIIIc and XVII have been prepared from 2-amino-3-cyanopyrazines I via reactions of I with alkanediamines II - IV and subsequent condensation of the resulting intermediates V - VII with orthoesters VIII, aldehydes X and ketones XIV.