Collect. Czech. Chem. Commun. 1990, 55, 1854-1865

Preparation and properties of 2-(dialkylaminomethyl)cyclohexyl and 2-(dialkylaminomethyl)phenyl carbanilates

Alena Brádlerováa, Nadežda Prónayováb, Eva Mišíkováa and Ján Ďurindaa

a Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Comenius University, 832 32 Bratislava
b Central Laboratory of Chemical Technique, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava


A series of 2-(dialkylaminomethyl)cyclohexyl and 2-(dialkylaminomethyl)phenyl esters of substituted carbanilic acid have been prepared and their identity verified by elemental analysis and evaluation of IR and 13C NMR spectra. The spectral results have been used also for determination of isomerism of the starting 2-dialkylaminomethylcyclohexanols and final carbanilates. Local anaesthetic activity and acute toxicity have been tested with some of the substances.