Collect. Czech. Chem. Commun. 1990, 55, 1769-1776

Steric effects in alkaline solvolysis of diaryl anilidophosphates

František Kašpáreka, Kamila Vavčíkováa, Jiří Mollina and Aleš Husekb

a Department of Inorganic and Physical Chemistry, Palacký University, 771 46 Olomouc
b Department of Medicinal Chemistry, Palacký University, 775 15 Olomouc


Analysis of the products of solvolysis of aryl esters of anilidophosphoric acids in water-2-propanol mixture excludes that the reaction proceeds via E1cB mechanism. Analysis of the reaction products of solvolysis of methyl-substituted compounds made it possible to evaluate the importance of the reported steric hindrance by CH3 group. The dependence of rate constants of the solvolysis on solvent system has been established.