Collect. Czech. Chem. Commun.
1990, 55, 1586-1601
https://doi.org/10.1135/cccc19901586
Modified syntheses of 2-(methylthio)-10-(2-(1-methyl-2-piperidinyl)ethyl)phenothiazine (thioridazine) and 1-(3-(2-(methylsulfonyl)-10-phenothiazinyl)propyl)-piperidine-4-carboxamide (metopimazine)
Karel Šindelář, Jiří Holubek, Ivan Koruna, Marta Hrubantová and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Crossref Cited-by Linking
- Karicherla Venumanikanta, Phani Kumar, Bodireddy Mohan Reddy, Prashanth Kumar Babu, Gajula Madhusudana Rao, Pramod Kumar: A Simple and Commercially Viable Process for Improved Yields of Metopimazine, a Dopamine D2-Receptor Antagonist. Org. Process Res. Dev. 2017, 21, 720. <https://doi.org/10.1021/acs.oprd.7b00052>
- Takács Daniella, Nagy Ildikó, Bombicz Petra, Egyed Orsolya, Jemnitz Katalin, Riedl Zsuzsanna, Molnár József, Amaral Leonard, Hajós György: Selective hydroboration of dieneamines. Formation of hydroxyalkylphenothiazines as MDR modulators. Bioorganic & Medicinal Chemistry 2012, 20, 4258. <https://doi.org/10.1016/j.bmc.2012.05.065>
- SINDELAR K., HOLUBEK J., KORUNA I., HRUBANTOVA M., PROTIVA M.: ChemInform Abstract: Modified Syntheses of 2‐(Methylthio)‐10‐(2‐(1‐methyl‐2‐piperidinyl)ethyl)phenothiazine (Thioridazine) and 1‐(3‐(2‐(Methylsulfonyl)‐10‐phenothiazinyl)propyl)piperidine‐4‐carboxamide (Metopimazine). ChemInform 1990, 21. <https://doi.org/10.1002/chin.199041216>
