Collect. Czech. Chem. Commun.
1990, 55, 797-808
https://doi.org/10.1135/cccc19900797
Potential neuroleptics of the orthopramide series; Synthesis of N-(3-(tert.amino)propyl)-5-sulfamoyl-2-methoxybenzamides
Vladimír Valenta, Marie Vlková, Jiří Holubek, Emil Svátek, Jiřina Metyšová and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert.amino)propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series. Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.
