Collect. Czech. Chem. Commun. 1990, 55, 761-765
https://doi.org/10.1135/cccc19900761

Preparation of N-protected α-amino alcohols by acetoxyborohydride reduction of N-protected α-amino acid esters

Milan Souček, Ján Urban and David Šaman

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6

Abstract

N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature. The reductions proceed with excellent yields and without racemisation. Reduction of the carbamate protecting groups was not observed.