Collect. Czech. Chem. Commun. 1990, 55, 575-580

Antiarrhythmic activity of a novel analogue of AAP

Bijoy Kundua, Shaheena Yasmeen Rizvia, Krishna Behari Mathura and Kurunamoy Karb

a Division of Biopolymers, Central Drug Research Institute, Lucknow 226 001, India
b Division of Pharmacology, Central Drug Research Institute, Lucknow 226 001, India


Three novel analogues of antiarrhythmic peptide (AAP), [Sar2, Pro3]AAP (I), [Sar3]AAP (II) and [Sar2, Sar3]AAP (III), have been synthesized in order to get peptides with enhanced antiarrhythmic activity. Their antiarrhythmic activity has been evaluated against aconitine induced arrhythmia in rats. [Sar2, Sar3]AAP has been found to be more active than AAP. It is equipotent to the commonly used antiarrhythmic drug quinidine, so far as delay in the onset of ventricular tachycardia, ventricular fibrillation and cardiac arrest are concerned. Relationship of biological activities of these peptides with their CD is discussed. The results suggest that the spatial structure of III attributed to Sar2-Sar3 linkage might be contributing to its higher antiarrhythmic activity.