Collect. Czech. Chem. Commun. 1990, 55, 3008-3014

Synthesis and some biological properties of analogue of angiotensin with modified proline structure

Zdenko Procházkaa, Yuris E. Ancansb, Nataliya V. Myshlyakovab, Marita P. Ratkevichb and Gunta M. Strazdab

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Institute of Organic Synthesis, Latvian Academy of Sciences, Riga, U.S.S.R.


The [1-asparagine]angiotensin analogue was synthesized by fragment condensation employing the azide method. Proline in the position 7 in this analogue and phenylalanine in the position 8 were substituted with 2-[1-(2-oxo-3-aminopyrrolidinyl)]-3-phenylpropanoic acid. The analogue does not exhibit any agonistic nor antagonistic activity in myotropic, histamin releasing and pressoric tests.