Collect. Czech. Chem. Commun. 1990, 55, 2731-2737

Synthesis and conformation of some 6-aminomethyluracil amides

Ivan Stibor, David Šaman and Pavel Fiedler

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


Three model amides (I-III) derived from 6-(N-alkylaminomethyl)-uracil and arylcarboxylic acids were synthesized and their conformation in solution studied. The 7-membered intramolecular hydrogen bond between amide carbonyl and H-N1 of uracil nucleus was proved to exist in solution of all three compounds using NMR and IR spectroscopy.