Collect. Czech. Chem. Commun. 1990, 55, 2493-2501

Synthesis and 1H and 13C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity

Karel Dlabala, Karel Paláta, Antonín Lyčkab and Želmíra Odlerovác

a Faculty of Pharmacy, Charles University, 501 65 Hradec Králové
b Research Institute of Organic Syntheses, 532 18 Pardubice-Rybitví
c Research Institute of Preventive Medicine, 833 01 Bratislava


Homolytic amidations of 2-chloropyrazine and 6-chloropyrazine-2-carbonitrile have been carried out to obtain products which have been used to prepare sulfur derivatives of pyrazine as potential tuberculostatic agents. The 1H and 13C NMR spectra of the products have been measured and interpreted, and the antituberculotic activity has been evaluated.