Collect. Czech. Chem. Commun. 1989, 54, 2513-2518

Effect of soybean extract on nitrosamines formation. In vitro study

Nadia I. Zakharya, Abdelbaset A. El-Aasera and Camelia A. Abdel-Malakb

a Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
b Chemistry Department, Faculty of science Damietta, Mansoura University, Egypt


Soybean (SB) extracts markedly inhibit formation of diphenylnitrosamine (DPNA) from the precursors diphenylamine (DPA) and nitrite (NO2-). SB extracts interact with nitrite, as shown by the decrease in the nitrite level. The rate of interaction between SB extracts and nitrite was lower than the rate of inhibition of DPNA formation. Thus the reduction of DPNA yield by SB extracts is not caused mainly through their competition for the available nitrite, but it might be due to the adsorption of the DPNA formed to the SB proteins, internitrosation between SB constituents and DPNA formed, or through the breakdown of the DPNA.