Collect. Czech. Chem. Commun.
1989, 54, 2248-2260
https://doi.org/10.1135/cccc19892248
Potential anticonvulsants: 3-Chlorobenzophenone derivatives
Jiří Jílek, Jiří Urban, Vojtěch Kmoníček, Josef Pomykáček, Jiří Holubek, Emil Svátek, Oluše Matoušová, Jan Metyš, Martin Valchář, Stanislav Wildt and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Reactions of 2-(2-iodoacetamido)-5-chlorobenzophenone with 2-amino-2-phenylethanol, 2-amino-1-phenylethanol, 3-amino-2-phenylpropanol, D-(+)-norpseudoephedrine, and 2-aminopropane-2-carbonitrile gave the 2-substituted N-(2-benzoyl-4-chlorophenyl)acetamides X-XIV. 2,3'-Dichlorobenzhydrol (XVI) and 2,3'-dichlorobenzhydryl chloride (XIX) were transformed to the ethers XVII and XVIII and to the amines XXI-XXIV. Compound XVI was oxidized to the ketone XXV which was transformed via the oxime XXVI to compound XXVII. The basic products were converted to salts which were pharmacologically tested. Compounds X, XVII, XXIII, and XXVII showed anticonvulsant effects and some other neurotropic activities.
