Collect. Czech. Chem. Commun. 1989, 54, 1940-1954

Preparation, spectral and physicochemical characteristics of methylamide Nα-phenylthiocarbamoyl derivatives of naturally occurring amino acids

Manfred Pavlíka, Ivan Kluha, Františka Pavlíkováb, Soňa Vašíčkováa and Vladimír Kostkaa

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Prague Institute of Chemical Technology, 166 28 Prague 6


The methylamide Nα-phenylthiocarbamoyl derivatives of encoded amino acids II were prepared either by the addition of phenylisothiocyanate to amino acid methylamides or by the treatment of amino acid phenylthiohydantoins (5-alkyl-3-phenyl-2-thioxo-4-imidazolinones) I with methylamine. The derivatives were prepared of 19 amino acids and their melting points, 1H NMR, 13C NMR, mass, ultraviolet and infrared spectra were measured.