Collect. Czech. Chem. Commun. 1989, 54, 1422-1430

Synthesis and CD characteristics of position 3 analogues of antiarrhythmic peptide

Bijoy Kundu

Division of Biopolymers, Central Drug Research Institute, Lucknow 226 001, India


Six analogues of the antiarrhythmic peptide (Gly-Pro-Hyp-Gly-Ala-Gly), in which Hyp at position 3 has been replaced with other amino acids such as Gly, Ala, D-Ala, Ser, Thr and Lys have been synthesized. The compounds were obtained by a stepwise peptide coupling strategy in solution. A relationship between antiarrhythmic activities and CD spectra has been discussed.