Collect. Czech. Chem. Commun. 1989, 54, 498-505

Study of conformation of α-narcotine N-oxide and related compounds

Dušan Uhrín and Bohumil Proksa

Chemical Institute, Chemical Research Center, Slovak Academy of Sciences, 842 38 Bratislava


Conformation of quaternary derivatives of (-)-α-narcotine (I) in solution was investigated using α-narcotine N-oxide hydrochloride (IV) as the model compound. In solution, compound IV exists predominantly in the form with torsion angle H-C(1)-C(9)-H of about 270° and with half-chair conformation of the isoquinoline tetrahydropyridine ring.