Collect. Czech. Chem. Commun. 1989, 54, 361-369
https://doi.org/10.1135/cccc19890361

Spectrophotometric and polarographic study of the efficiency of the chemical destruction of some antineoplastic pharmaceuticals

Jiří Barek and Jiří Zima

Department of Analytical Chemistry, Charles University, 128 40 Prague 2, Czechoslovakia

Abstract

The efficiency of the chemical destruction of some antineoplastic pharmaceuticals was studied using visible and ultraviolet spectrophotometry and differential pulse polarography. Doxorubicin, Daunorubicin, Vincristine, Vinblastine, Methotrexate and Dichlomethotrexate are destroyed best by oxidatin with potassium permanganate, while some derivatives of N-nitrosourea (Lomustine, Chlorozotocin) are best destroyed by denitrosation with hydrobromic acid. The efficiency of the decomposition can readily be studied by spectrophotometry or differential pulse polarography.