Collect. Czech. Chem. Commun.
1989, 54, 361-369
https://doi.org/10.1135/cccc19890361
Spectrophotometric and polarographic study of the efficiency of the chemical destruction of some antineoplastic pharmaceuticals
Jiří Barek and Jiří Zima
Department of Analytical Chemistry, Charles University, 128 40 Prague 2, Czechoslovakia
Abstract
The efficiency of the chemical destruction of some antineoplastic pharmaceuticals was studied using visible and ultraviolet spectrophotometry and differential pulse polarography. Doxorubicin, Daunorubicin, Vincristine, Vinblastine, Methotrexate and Dichlomethotrexate are destroyed best by oxidatin with potassium permanganate, while some derivatives of N-nitrosourea (Lomustine, Chlorozotocin) are best destroyed by denitrosation with hydrobromic acid. The efficiency of the decomposition can readily be studied by spectrophotometry or differential pulse polarography.
