Collect. Czech. Chem. Commun.
1989, 54, 229-234
https://doi.org/10.1135/cccc19890229
Potential antidepressants: 2-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4,5-dihydroimidazoles
Karel Šindelář, Jiřina Metyšová and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Reactions of 2-substituted 11-chloro-6,11-dihydrodibenzo[b,e]thiepins with trimethylsilyl cyanide in dichloromethane in the presence of stannic chloride afforded nitriles IIb-IId in high yields. Heating of IIa-IId with 2-aminoethylammonium toluene-4-sulfonate to 200 °C gave the title compounds Ia-Id which were transformed to hydrogen maleates. Compound Ic (hydrogen maleate VÚFB-17 092) showed in several tests a clear thymoleptic (potential antidepressant) character.
