Collect. Czech. Chem. Commun. 1988, 53, 671-685

A description of effect of composition of mixed binary solvents on processes in solutions

Oldřich Pytela and Miroslav Ludwig

Department of Organic Chemistry, Institute of Chemical Technology, 532 10 Pardubice


A theoretical description of the effect of changed composition of mixed solvents on processes in solutions has been suggested on the basis of the proportionality between the Gibbs energy change of the process and that of the solvent due to the transition from pure components to the mixture. The additional Gibbs energy has been expressed by means of the so-called classical functions by Margules, van Laar-Wohl, and van Laar-Null. The application to 115 various processes (pK, IR, UV-VIS, NMR, log k, and others) has confirmed that the theoretical presumptions are justified, the most suitable being Margules' 4th order model which shows a statistically significant difference from the models of lower orders.