Collect. Czech. Chem. Commun. 1988, 53, 2914-2919

Synthesis and biological activity of new metallocenic angiotensin II analogs

Pierrette Maesa, Annie Ricouarta, Emmanuel Escherb, André Tartara and Christian Sergheraerta

a Service de Chimie des Biomolécules, Institut Pasteur de Lille, 59019 Lille, France
b Département de Physiologie et Pharmacologie, CHU Sherbrooke, J1H 5N4 Quebec, Canada


Analogs of angiotensin II in which phenylalanine in position 8 was replaced with cymantrenylalanine or with its triphenylphosphine photosubstitution product were synthesized by the solid-phase method. On rabbit aorta strips, these peptides were found to be pure antagonists of angiotensin II. Their relative affinities are higher than most other analogs substituted in position 8 with bulky amino-acids.