Collect. Czech. Chem. Commun. 1988, 53, 2897-2906

Muramyl-dipeptide analogues: Synthesis and biological activities

Jan Ježeka, Milan Zaorala, Miloš Buděšínskýa, Jiří Günthera and Jiří Rottab

a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Institute of Hygiene and Epidemiology, 100 42 Prague 10


In the search for immunoadjuvant active compounds without pyrogenic activity we prepared N-Ac-norMur-L-Abu-D-Gln-O-Bu (V), N-Ac-Mur-L-Abu-D-Gln-O-Bu (VII) and their respective α-benzylglycosides VI and VIII. All the prepared compounds are nonpyrogenic. In the delayed hypersensitivity test, compound V is inactive, VI is comparable to MDP, VII is more and VIII is less active than MDP.