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Collect. Czech. Chem. Commun. 1988, 53, 2884-2889

Specific water-soluble substrates for chymotrypsin: Attempts for compensating diminished P1-S1 interactions

Volker Schellenberger, Ute Schellenberger and Hans-Dieter Jakubke

Karl-Marx-University, Biosciences Division, Department of Biochemistry, DDR - 7010 Leipzig, G.D.R.

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  • Beck-Piotraschke Karin, Jakubke Hans-Dieter: Protease-catalysed synthesis of peptides containing histidine and lysine. Tetrahedron: Asymmetry 1998, 9, 1505. <>
  • Schelhaas Michael, Glomsda Simone, Hänsler Marion, Jakubke Hans-Dieter, Waldmann Herbert: Enzymatische Synthese von Peptiden undRas-Lipopeptiden unter Verwendung des Cholinesters als löslichkeitsvermittelnder Schutz- und Aktivierungsgruppe. Angew. Chem. 1996, 108, 82. <>
  • Occhiato Ernesto, Bryan Jones J.: Probing enzyme stereospecificity. Inhibition of α-chymotrypsin and subtilisin Carlsberg by chiral amine- and aminoalcohol-derivatives. Tetrahedron 1996, 52, 4199. <>
  • Gololobov Mikhail Yu., Stepanov Valentin M., Voyushina Tatjana L., Morozova Irina P., Adlercreutz Patrick: Side reactions in enzymatic peptide synthesis in organic media: Effects of enzyme, solvent, and substrate concentrations. Enzyme Microbiology Technology 1994, 16, 522. <>
  • Calvet Silvia, Clap��s Pere, Torres Josep L., Valencia Gregori, Feixas Joan, Adlercreutz Patrick: Enzymatic synthesis of X-Phe-Leu-NH2 in low water content systems: Influence of the N-�� protecting group and the reaction medium composition. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1993, 1164, 189. <>
  • GOLOLOBOV Mikhail Y., STEPANOV Valentin M., VOYUSHINA Tatjana L., ADLERCREUTZ Patrick: The second nucleophile molecule binds to the acyl-enzyme-nucleophile complex in alpha-chymotrypsin catalysis. Kinetic evidence for the interaction. Eur J Biochem 1993, 217, 955. <>
  • Gololobov Mikhail Yu., Voyushina Tatyana L., Stepanov Valentin M., Adlercreutz Patrick: Nucleophile specificity in ��-chymotrypsin- and subtilisin-(Bacillus subtilis strain 72) catalyzed reactions. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1992, 1160, 188. <>
  • SCHELLENBERGER Volker, BRAUNE Katrin, HOFMANN Hans-Jorg, JAKUBKE Hans-Dieter: The specificity of chymotrypsin. A statistical analysis of hydrolysis data. Eur J Biochem 1991, 199, 623. <>
  • SCHELLENBERGER Volker, SCHELLENBERGER Ute, MITIN Yuri V., JAKUBKE Hans-Dieter: Characterization of the S'-subsite specificity of bovine pancreatic alpha-chymotrypsin via acyl transfer to added nucleophiles. Eur J Biochem 1990, 187, 163. <>