Collect. Czech. Chem. Commun. 1988, 53, 2583-2590

Configurational requirements of aromatic amino acid residues for the activity of PRP-hexapeptide

Aleksandra Kubika, Zbigniew Szewczuka, Ignacy Z. Siemiona, Zbigniew Wieczorekb, Krystyna Spiegelb, Michal Zimeckib, Maria Januszb and Józef Lisowskib

a Institute of Chemistry, University of Wrocław, 50-383 Wrocław, Poland
b Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland


The three analogues with D-amino acid substituents at position 1 and 5 of PRP-hexapeptide were synthesized and tested for its biological activity to check the influence of the spacial orientation of aromatic rings on the immune response. One of the analogs (Tyr-Val-Pro-Leu-D-Phe-Pro) was found to have the immunoregulatory activity.