Collect. Czech. Chem. Commun. 1987, 52, 2274-2280

New intermediate for rapid synthesis of N-isopropyl-2-amino-1-(4-iodophenyl)propane (N-isopropyl-4-iodoamphetamine), labelled with radioactive iodine

Jiří Protivaa, Václav Křečeka, Ladislav Lešetickýa and Petr Sedmerab

a Department of Organic Chemistry, Charles University, 128 40 Prague 2
b Microbiological Institute, Czechoslovak Academy of Sciences, 142 20 Prague 4


The triazene derivative of N-isopropyl-2-amino-1-phenylpropane XIV, synthesized in seven steps from 2-amino-1-phenylpropane (II), enables a rapid, simple and regiospecific preparation of N-isopropyl-2-amino-1-(4-iodophenyl)propane (N-isopropyl-4-iodoamphetamine; I), labelled with short-living isotopes of iodine, directly prior to application.