Collect. Czech. Chem. Commun.
1987, 52, 2274-2280
https://doi.org/10.1135/cccc19872274
New intermediate for rapid synthesis of N-isopropyl-2-amino-1-(4-iodophenyl)propane (N-isopropyl-4-iodoamphetamine), labelled with radioactive iodine
Jiří Protivaa, Václav Křečeka, Ladislav Lešetickýa and Petr Sedmerab
a Department of Organic Chemistry, Charles University, 128 40 Prague 2
b Microbiological Institute, Czechoslovak Academy of Sciences, 142 20 Prague 4
Abstract
The triazene derivative of N-isopropyl-2-amino-1-phenylpropane XIV, synthesized in seven steps from 2-amino-1-phenylpropane (II), enables a rapid, simple and regiospecific preparation of N-isopropyl-2-amino-1-(4-iodophenyl)propane (N-isopropyl-4-iodoamphetamine; I), labelled with short-living isotopes of iodine, directly prior to application.
