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Collect. Czech. Chem. Commun. 1987, 52, 788-792

Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity

Stanislav Rádl and Viktor Zikán

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3

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  • Teixeira Fátima C., Lucas Carla, Curto M. João M., André Vânia, Duarte M. Teresa, Teixeira António P. S.: Synthesis of novel pyrazolo[3,4-b]quinolinebisphosphonic acids and an unexpected intramolecular cyclization and phosphonylation reaction. Org. Biomol. Chem. 2021, 19, 2533. <>
  • Marjani Ahmad Poursattar, Khalafy Jabbar, Akbarzadeh Somayeh: Synthesis of pyrazolopyridine and pyrazoloquinoline derivatives by one-pot, three-component reactions of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide. Green Processing and Synthesis 2019, 8, 533. <>
  • Ezzati Mahnaz, Khalafy Jabbar, Marjani Ahmad Poursattar, Prager Rolf H.: The catalyst-free syntheses of pyrazolo[3,4-b]quinolin-5-one and pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidin-5,7-dione derivatives by one-pot, three-component reactions. Tetrahedron 2017, 73, 6587. <>
  • Arasakumar Thangaraj, Mathusalini Sadasivam, Lakshmi Krishnasamy, Mohan Palathurai Subramaniam, Ata Athar, Lin Chia-Her: Object-oriented synthetic approach toward angular and linear fused pyrazoloquinolines of biological importance with InCl3 catalyst. Synthetic Communications 2016, 46, 232. <>
  • Kumara Tholappanavara H. Suresha, Nagendrappa Gopalpur, Chandrika Nanjappa, Sowmya Haliwana B. V., Kaur Manpreet, Jasinski Jerry P., Glidewell Christopher: Reactions between arylhydrazinium chlorides and 2-chloroquinoline-3-carbaldehydes: molecular and supramolecular structures of a hydrazone, a 4,9-dihydro-1H-pyrazolo[3,4-b]quinoline and two 1H-pyrazolo[3,4-b]quinolines. Acta Crystallogr C Struct Chem 2016, 72, 670. <>
  • Elgemeie G.H., Ahmed K.A., Ahmed E.A., Helal M.H., Masoud D.M.: Microwave assisted one-pot synthesis of pyrazoloquinazolinone derivatives and their application on printing of synthetic fabrics. Pigment & Resin Technology 2015, 44, 165. <>
  • Bhavsar Dinesh C., Nikam Prashant S., Gangurde Sachin A., Toche Raghunath B.: Synthesis of Polysubstituted Pyrazolo[3,4-b ]pyridine-3-Carbohydrazide and Pyrazolo[3,4-d ]pyridazine Derivatives. J. Heterocyclic Chem. 2014, 51, 635. <>
  • Albin Randi, Chase Robert, Risano Christine, Lieberman Melvin, Ferrari Eric, Skelton Angela, Buontempo Peter, Cox Stuart, DeMartino Jason, Wright-Minogue Jacquelyn, Jirau-Lucca Gilbert, Kelly Joseph, Afonso Adrian, Kwong Ann D, Rozthon Edward J, O'Connell John F: SCH 43478 and analogs: in vitro activity and in vivo efficacy of novel agents for herpesvirus type 2. Antiviral Research 1997, 35, 139. <>