Collect. Czech. Chem. Commun. 1987, 52, 2983-2990
https://doi.org/10.1135/cccc19872983

Some dopaminergically active esters of N-[(5R,8S,10R)-6-propyl-8-ergolinyl]carbamic acid with cancerogenicity manifestations

Antonín Černý, Jiří Křepelka, Karel Řežábek, Maria Frühaufová, Václav Plaisner and Jiří Holda

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3

Abstract

Esters of N-[(5R,8S,10R)-6-propyl-8-ergolinyl]carbamic acid I-VI were prepared from (5R,8S,10R)-6-propyl-8-ergolinecarboxylic acid hydrazide (VIII) via the azide IX and isocyanate X or via (5R,8S,10R)-6-propyl-8-aminoergoline (XI). Some of the prepared esters exhibited strong dopaminergic activity in the neuro-endocrine region; some tests indicate possible cancerogenicity and mutagenicity of the ethyl ester II.