Collection of Czechoslovak Chemical Communications - digital archive 

Crossref Cited-by Linking

• Bessières Maximes, Roy Vincent, Abuduani Tuniyazi, Favetta Patrick, Snoeck Robert, Andrei Graciela, Moffat Jennifer, Gallardo Franck, Agrofoglio Luigi A.: Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses. European Journal of Medicinal Chemistry 2024, 271, 116412. <https://doi.org/10.1016/j.ejmech.2024.116412>
• Vaňková Karolína, Keough Dianne T., Hocková Dana, Guddat Luke W., Janeba Zlatko: N2′‐Branched Acyclic Nucleoside Phosphonates Containing 9‐Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6‐Oxopurine Phosphoribosyltransferase. ChemMedChem 2023, 18. <https://doi.org/10.1002/cmdc.202300211>
• Kraina Pavel, Česnek Michal, Tloušťová Eva, Mertlíková-Kaiserová Helena, Fulton Camryn J., Davidson Emily K., Smith Brenton P., Watts Val J., Janeba Zlatko: Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir. Bioorganic & Medicinal Chemistry 2023, 95, 117508. <https://doi.org/10.1016/j.bmc.2023.117508>
• Česnek Michal, Šafránek Michal, Dračínský Martin, Tloušťová Eva, Mertlíková‐Kaiserová Helena, Hayes Michael P., Watts Val J., Janeba Zlatko: Halogen‐Dance‐Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2‐Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases. ChemMedChem 2022, 17. <https://doi.org/10.1002/cmdc.202100568>
• Blindauer Claudia A., Holý Antonín, Sigel Astrid, Operschall Bert P., Griesser Rolf, Sigel Helmut: Acid–base properties of an antivirally active acyclic nucleoside phosphonate: (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA). New J. Chem. 2022, 46, 6484. <https://doi.org/10.1039/D2NJ00543C>
• Břehová Petra, Chaloupecká Ema, Česnek Michal, Skácel Jan, Dračínský Martin, Tloušťová Eva, Mertlíková-Kaiserová Helena, Soto-Velasquez Monica P., Watts Val J., Janeba Zlatko: Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases. European Journal of Medicinal Chemistry 2021, 222, 113581. <https://doi.org/10.1016/j.ejmech.2021.113581>
• Dietz Jule-Philipp, Ferenc Dorota, Jamison Timothy F., Gupton B. Frank, Opatz Till: Di-tert-butyl Phosphonate Route to the Antiviral Drug Tenofovir. Org. Process Res. Dev. 2021, 25, 789. <https://doi.org/10.1021/acs.oprd.0c00473>
• Majerová Taťána, Novotný Pavel: Precursors of Viral Proteases as Distinct Drug Targets. Viruses 2021, 13, 1981. <https://doi.org/10.3390/v13101981>
• Malnuit Vincent, Smoleń Sabina, Tichý Michal, Poštová Slavětínská Lenka, Hocek Michal: Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6‐(Thiophen‐2‐yl)‐7‐fluoro‐7‐deazapurine. Eur J Org Chem 2019, 2019, 5409. <https://doi.org/10.1002/ejoc.201900509>
• Frydrych Jan, Skácel Jan, Šmídková Markéta, Mertlíková‐Kaiserová Helena, Dračínský Martin, Gnanasekaran Ramachandran, Lepšík Martin, Soto‐Velasquez Monica, Watts Val J., Janeba Zlatko: Synthesis of α‐Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases. ChemMedChem 2018, 13, 199. <https://doi.org/10.1002/cmdc.201700715>
• Česnek Michal, Skácel Jan, Jansa Petr, Dračínský Martin, Šmídková Markéta, Mertlíková‐Kaiserová Helena, Soto‐Velasquez Monica P., Watts Val J., Janeba Zlatko: Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis. ChemMedChem 2018, 13, 1779. <https://doi.org/10.1002/cmdc.201800332>
• Seley-Radtke Katherine L., Yates Mary K.: The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold. Antiviral Research 2018, 154, 66. <https://doi.org/10.1016/j.antiviral.2018.04.004>
• Shen Guang Huan, Hong Joon Hee: Recent advances in the synthesis of cyclic 5′-nornucleoside phosphonate analogues. Carbohydrate Research 2018, 463, 47. <https://doi.org/10.1016/j.carres.2018.04.009>
• Laux Wolfgang HG, Priet Stéphane, Alvarez Karine, Peyrottes Suzanne, Périgaud Christian: Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine. Antivir Chem Chemother 2018, 26. <https://doi.org/10.1177/2040206618757636>
• Baszczyňski Ondřej, Kaiser Martin Maxmilian, Česnek Michal, Břehová Petra, Jansa Petr, Procházková Eliška, Dračínský Martin, Snoeck Robert, Andrei Graciela, Janeba Zlatko: Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus. Antivir Chem Chemother 2018, 26. <https://doi.org/10.1177/2040206618813050>
• Břehová Petra, Šmídková Markéta, Skácel Jan, Dračínský Martin, Mertlíková‐Kaiserová Helena, Velasquez Monica P. Soto, Watts Val J., Janeba Zlatko: Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases. ChemMedChem 2016, 11, 2534. <https://doi.org/10.1002/cmdc.201600439>
• Sabat Nazarii, Poštová Slavětínská Lenka, Klepetářová Blanka, Hocek Michal: C–H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives. J. Org. Chem. 2016, 81, 9507. <https://doi.org/10.1021/acs.joc.6b01970>
• Justa N., Weber K., Klein D., Mueller R.S., Sauter‐Louis C., Hartmann K.: Retracted: Efficacy and Adverse Effects of (R)‐9‐(2‐phosphonylmethoxypropyl)‐2,6‐diaminopurine in Feline Immunodeficiency Virus‐Infected Cats. Veterinary Internal Medicne 2012, 26, 1267. <https://doi.org/10.1111/j.1939-1676.2012.01007.x>
• Vávrová Kateřina, Kovaříková Petra, Školová Barbora, Líbalová Martina, Roh Jaroslav, Čáp Robert, Holý Antonín, Hrabálek Alexandr: Enhanced Topical and Transdermal Delivery of Antineoplastic and Antiviral Acyclic Nucleoside Phosphonate cPr-PMEDAP. PHARMA RES 2011, 28, 3105. <https://doi.org/10.1007/s11095-011-0508-4>
• Barral Karine, Weck Clément, Payrot Nadine, Roux Loic, Durafour Céline, Zoulim Fabien, Neyts Johan, Balzarini Jan, Canard Bruno, Priet Stéphane: Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication. Eur Med Chem 2011, 46, 4281. <https://doi.org/10.1016/j.ejmech.2011.06.034>
• Doláková Petra, Dračínský Martin, Fanfrlík Jindřich, Holý Antonín: Synthesis of Analogues of Acyclic Nucleoside Diphosphates Containing a (Phosphonomethyl)phosphanyl Moiety and Studies of Their Phosphorylation. Eur J Org Chem 2009, 2009, 1082. <https://doi.org/10.1002/ejoc.200800911>
• Fernández-Botello Alfonso, Holý Antonín, Moreno Virtudes, Operschall Bert P., Sigel Helmut: Intramolecular π–π stacking interactions in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and the nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antivirally active 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Inorganica Chimica Acta 2009, 362, 799. <https://doi.org/10.1016/j.ica.2008.02.035>
• Vávrová Kateřina, Lorencová Kateřina, Klimentová Jana, Novotný Jakub, Holý Antonı´n, Hrabálek Alexandr: Transdermal and dermal delivery of adefovir: Effects of pH and permeation enhancers. European Journal of Pharmaceutics and Biopharmaceutics 2008, 69, 597. <https://doi.org/10.1016/j.ejpb.2007.12.005>
• Vávrová Kateřina, Lorencová Kateřina, Novotný Jakub, Holý Antonín, Hrabálek Alexandr: Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: Influence of pH, ion-pairing and skin species. European Journal of Pharmaceutics and Biopharmaceutics 2008, 70, 901. <https://doi.org/10.1016/j.ejpb.2008.07.002>
• Reddy K. Raja, Matelich Michael C., Ugarkar Bheemarao G., Gómez-Galeno Jorge E., DaRe Jay, Ollis Kristin, Sun Zhili, Craigo William, Colby Timothy J., Fujitaki James M., Boyer Serge H., van Poelje Paul D., Erion Mark D.: Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B. J. Med. Chem. 2008, 51, 666. <https://doi.org/10.1021/jm7012216>
• Korovina A. N., Yasco M. V., Ivanov A. V., Khandazhinskaya A. L., Karamov E. V., Kornilaeva G. V., Kukhanova M. K.: Novel herpes simplex virus and human immunodeficiency virus inhibitors based on phosphonate nucleoside analogs. Moscow Univ. Chem. Bull. 2008, 63, 85. <https://doi.org/10.3103/S0027131408020089>
• Tang Yan-bo, Peng Zong-gen, Liu Zong-ying, Li Yan-ping, Jiang Jian-dong, Li Zhuo-rong: Some new acyclic nucleotide analogues as antiviral prodrugs: Synthesis and bioactivities in vitro. Biorg Med Chem Lett 2007, 17, 6350. <https://doi.org/10.1016/j.bmcl.2007.08.065>
• Točík Zdeněk, Dvořáková Ivana, Liboska Radek, Buděšínský Miloš, Masojídková Milena, Rosenberg Ivan: Electrophile-promoted addition of hydroxymethylphosphonate to 4′,5′-didehydronucleosides: a way to novel isosteric analogues of 5′-nucleotides. Tetrahedron 2007, 63, 4516. <https://doi.org/10.1016/j.tet.2007.03.059>
• Frangeul Antoine, Barral Karine, Alvarez Karine, Canard Bruno: In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5′-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives. Antimicrob Agents Chemother 2007, 51, 3162. <https://doi.org/10.1128/AAC.00145-07>
• Králíková Šárka, Buděšínský Miloš, Tomečková Ivana, Rosenberg Ivan: Oxidative cleavage of ribofuranose 5-(α-hydroxyphosphonates): a route to erythrofuranose-based nucleoside phosphonic acids. Tetrahedron 2006, 62, 9742. <https://doi.org/10.1016/j.tet.2006.07.056>
• Kotian Pravin L., Kumar V. Satish, Lin Tsu-Hsing, El-Kattan Yahya, Ghosh Ajit, Wu Minwan, Cheng Xiaogang, Bantia Shanta, Babu Yarlagadda S., Chand Pooran: An Efficient Synthesis Of Acyclic N⁷- and N⁹-Adenine Nucleosides Via Alkylation With Secondary Carbon Electrophiles to Introduce Versatile Functional Groups At the C-1 Position of Acyclic Moiety. Nucleos Nucleot Nucl Acids 2006, 25, 121. <https://doi.org/10.1080/15257770500446816>
• Pechar Michal, Braunová Alena, Šubr Vladimír, Ulbrich Karel, Holý Antonín: Polymeric Conjugates of 9-[2-(Phosphonomethoxy)ethyl]purine with Potential Antiviral and Cytostatic Activity. Collect. Czech. Chem. Commun. 2006, 71, 1211. <https://doi.org/10.1135/cccc20061211>
• Clercq Erik De, Holý Antonín: Acyclic nucleoside phosphonates: a key class of antiviral drugs. Nat Rev Drug Discov 2005, 4, 928. <https://doi.org/10.1038/nrd1877>
• Laux Wolfgang H.G., Pande Praveen, Shoshani Ilana, Gao Junyuan, Boudou-Vivet Valérie, Gosselin Gilles, Johnson Roger A.: Pro-nucleotide Inhibitors of Adenylyl Cyclases in Intact Cells. Journal of Biological Chemistry 2004, 279, 13317. <https://doi.org/10.1074/jbc.M309535200>
• Kopecký Vladimír, Mojzeš Peter, Burda Jaroslav V., Dostál Lubomír: Raman spectroscopy study of acid–base and structural properties of 9‐[2‐(phosphonomethoxy)ethyl]adenine in aqueous solutions. Biopolymers 2002, 67, 285. <https://doi.org/10.1002/bip.10111>
• Birkuš Gabriel, Hájek Miroslav, Kramata Pavel, Votruba Ivan, Holý Antonín, Otová Berta: Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ε*. Antimicrob Agents Chemother 2002, 46, 1610. <https://doi.org/10.1128/AAC.46.5.1610-1613.2002>
• Balzarini J., Pannecouque C., De Clercq E., Aquaro S., Perno C.-F., Egberink H., Holý A.: Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates. Antimicrob Agents Chemother 2002, 46, 2185. <https://doi.org/10.1128/AAC.46.7.2185-2193.2002>
• Kamiya Naohiro, Kubota Atsushi, Iwase Yumiko, Sekiya Kouichi, Ubasawa Masaru, Yuasa Satoshi: Antiviral Activities of MCC-478, a Novel and Specific Inhibitor of Hepatitis B Virus. Antimicrob Agents Chemother 2002, 46, 2872. <https://doi.org/10.1128/AAC.46.9.2872-2877.2002>
• Chen Huan‐Ming, Hosmane Ramachandra S.: Synthesis of a novel ring‐expanded (“fat”) nucleotide analogue of phosphonomethoxyethylguanine (PMEG) containing the imidazo[4,5‐e][1,3]diazepine ring system. Journal of Heterocyclic Chem 2001, 38, 1313. <https://doi.org/10.1002/jhet.5570380611>
• Cihlar Tomas, Ho Edmund S., Lin Deborah C., Mulato Andrew S.: HUMAN RENAL ORGANIC ANION TRANSPORTER 1 (hOAT1) AND ITS ROLE IN THE NEPHROTOXICITY OF ANTIVIRAL NUCLEOTIDE ANALOGS. Nucleosides, Nucleotides and Nucleic Acids 2001, 20, 641. <https://doi.org/10.1081/NCN-100002341>
• Gutierrez A. J., Prisbe E. J., Rohloff J. C.: DEALKYLATION OF PHOSPHONATE ESTERS WITH CHLOROTRIMETHYLSILANE. Nucleosides, Nucleotides and Nucleic Acids 2001, 20, 1299. <https://doi.org/10.1081/NCN-100002541>
• Chen Huan-Ming, Hosmane Ramachandra S.: ACYCLIC NUCLEOSIDE/NUCLEOTIDE ANALOGUES WITH AN IMIDAZOLE RING SKELETON. NUCLEOT NUCL 2001, 20, 1599. <https://doi.org/10.1081/NCN-100105250>
• Cihlar Tomas, Ho Edmund S.: Fluorescence-Based Assay for the Interaction of Small Molecules with the Human Renal Organic Anion Transporter 1. Analytical Biochemistry 2000, 283, 49. <https://doi.org/10.1006/abio.2000.4633>
• Bacchelli Corinne, Condom Roger, Patino Nadia, Aubertin Anne-Marie: Synthesis and Biological Activities of New Carbaacyclonucleosides and 1′-Oxaacyclonucleosides Related to Clitocine. NUCLEOT NUCL 2000, 19, 567. <https://doi.org/10.1080/15257770008035008>
• Biessen E. A. L., Valentijn A. R. P. M., Vrueh R. L. A., Van de Bilt E., Sliedregt L. A. J. M., Prince P., Bijsterbosch M. K., Boom J. H., Marel G. A., Abrahams P. J., Berkel T. J. C.: Novel hepatotrophic prodrugs of the antiviral nucleoside 9‐(2‐phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity. FASEB j. 2000, 14, 1784. <https://doi.org/10.1096/fj.99-0887com>
• de Vrueh Remco L. A., Rump Erik T., van de Bilt Erika, van Veghel Richard, Balzarini Jan, Biessen Erik A. L., van Berkel Theo J. C., Bijsterbosch Martin K.: Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B. Antimicrob Agents Chemother 2000, 44, 477. <https://doi.org/10.1128/AAC.44.3.477-483.2000>
• Alexander Petr, Holý Antonín, Buděšínský Miloš, Masojídková Milena: Synthesis of Acyclic Nucleotide Analogues Derived from N3-Substituted Isoguanine. Collect. Czech. Chem. Commun. 2000, 65, 1713. <https://doi.org/10.1135/cccc20001713>
• HO EDMUND S., LIN DEBORAH C., MENDEL DIRK B., CIHLAR TOMAS: Cytotoxicity of Antiviral Nucleotides Adefovir and Cidofovir Is Induced by the Expression of Human Renal Organic Anion Transporter 1. JASN 2000, 11, 383. <https://doi.org/10.1681/ASN.V113383>
• Birkuš Gabriel, Votruba Ivan, Holý Antonı́n, Otová Berta: 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases α, δ, ε, and ε∗. Biochemical Pharmacology 1999, 58, 487. <https://doi.org/10.1016/S0006-2952(99)00118-5>
• Shoshani Ilana, Laux Wolfgang H.G., Périgaud Christian, Gosselin Gilles, Johnson Roger A.: Inhibition of Adenylyl Cyclase by Acyclic Nucleoside Phosphonate Antiviral Agents. Journal of Biological Chemistry 1999, 274, 34742. <https://doi.org/10.1074/jbc.274.49.34742>
• Laux W. H. G., Périgaud C., Imbach J.-L., Gosselin G.: Synthesis of New PMEA Diphosphate Mimics. Nucleosides and Nucleotides 1999, 18, 1003. <https://doi.org/10.1080/15257779908041629>
• Cihlar Tomas, Lin Deborah C., Pritchard John B., Fuller Michael D., Mendel Dirk B., Sweet Douglas H.: The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1. Mol Pharmacol 1999, 56, 570. <https://doi.org/10.1124/mol.56.3.570>
• Kamp Walter, Schokker Johan, Cambridge Eric, De Jong Sem, Schuurman Rob, De Groot Tom, Boucher Charles AB: Effect of Weekly Adefovir (PMEA) Infusions on HIV-1 Virus Load: Results of a Phase I/II Study. Antiviral Therapy 1999, 4, 101. <https://doi.org/10.1177/135965359900400207>
• Hatse S., Naesens L., Degrève B., Segers C., Vandeputte M., Waer M., De Clercq E., Balzarini J.: Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats. Int J Cancer 1998, 76, 595. <https://doi.org/10.1002/(SICI)1097-0215(19980518)76:4<595::AID-IJC24>3.0.CO;2-5>
• Hatse S., Naesens L., Degrève B., Segers C., Vandeputte M., Waer M., De Clercq E., Balzarini J.: Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats. Int. J. Cancer 1998, 76, 595. <https://doi.org/10.1002/(SICI)1097-0215(19980518)76:4<595::AID-IJC24>3.0.CO;2-5>
• Hatse Sigrid, Naesens Lieve, De Clercq Erik, Balzarini Jan: Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. Biochemical Pharmacology 1998, 56, 851. <https://doi.org/10.1016/S0006-2952(98)00058-6>
• Kramata Pavel, Downey Kathleen M., Paborsky Lisa R.: Incorporation and Excision of 9-(2-Phosphonylmethoxyethyl)guanine (PMEG) by DNA Polymerase δ and ε in Vitro. Journal of Biological Chemistry 1998, 273, 21966. <https://doi.org/10.1074/jbc.273.34.21966>
• Dang Qun, Liu Van, Erion Mark D.: A New Regio-Defined Synthesis of PMEA. Nucleosides and Nucleotides 1998, 17, 1445. <https://doi.org/10.1080/07328319808003479>
• Hatse Sigrid, De Clercq Erik, Balzarini Jan: Enhanced 9-(2-Phosphonylmethoxyethyl)adenine Secretion by a Specific, Indomethacin-Sensitive Efflux Pump in a Mutant 9-(2-Phosphonylmethoxyethyl)adenine-Resistant Human Erythroleukemia K562 Cell Line. Mol Pharmacol 1998, 54, 907. <https://doi.org/10.1124/mol.54.5.907>
• Blindauer Claudia A., Emwas Abdul H., Holý Antonín, Dvořáková Hana, Sletten Einar, Sigel Helmut: Complex Formation of the Antiviral 9‐[2‐(Phosphonomethoxy)Ethyl]Adenine (PMEA) and of Its N 1, N 3, and N 7 Deaza Derivatives with Copper(II) in Aqueous Solution. Chemistry A European J 1997, 3, 1526. <https://doi.org/10.1002/chem.19970030922>
• Zídek Zdeněk, Franková Daniela, Holý Antonín, Boubelík Michael, Dráber Petr: Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine. Biochemical Pharmacology 1997, 54, 855. <https://doi.org/10.1016/S0006-2952(97)00228-1>
• Franchetti Palmarisa, Sheikha Ghassan Abu, Perlini Paolo, Farhat Farhat, Grifantini Mario, Perra Graziella, Milia Carlo, Putzolu Monica, Colla Paolo La, Marongiu Maria Elena: Synthesis of Unsaturated Analogues of 9-[2(Phosphono- Methoxy)Propyl]Guanine as Antiviral Agents. Nucleosides and Nucleotides 1997, 16, 1921. <https://doi.org/10.1080/07328319708002544>
• Endová Magdalena, Masojidková Milena, Rosenberg Ivan: Transprotection of N-Benzoylated Nucleobase Derivatives by Dialkylaminomethylene Group. Nucleosides and Nucleotides 1997, 16, 2151. <https://doi.org/10.1080/07328319708002565>
• Naesens L, Snoeck R, Andrei G, Balzarini J, Neyts J, De Clercq E: HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections. Antivir Chem Chemother 1997, 8, 1. <https://doi.org/10.1177/095632029700800101>
• Cihlar T, Chen MS: Incorporation of Selected Nucleoside Phosphonates and Anti-Human Immunodeficiency Virus Nucleotide Analogues into DNA by Human DNA Polymerases α, β and γ. Antivir Chem Chemother 1997, 8, 187. <https://doi.org/10.1177/095632029700800302>
• Arends S., Halteren E., Kamp W., Schokker J.: Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection. Pharm World Sci 1996, 18, 30. <https://doi.org/10.1007/BF00449687>
• Chen Wei, Flavin Michael T., Filler Robert, Xu Ze-Qi: Introduction of α-fluorophosphonomethyl ether functionality and its application to the synthesis of fluorinated acyclic phosphonate nucleosides. Tetrahetron Lett 1996, 37, 8975. <https://doi.org/10.1016/S0040-4039(96)02106-5>
• Chen Wei, Flavin Michael T., Filler Robert, Xu Ze-Qi: AN IMPROVED SYNTHESIS OF 9-[2-(DIETHOXYPHOSPHONOMETHOXY)ETHYL]ADENINE AND ITS ANALOGUES WITH OTHER PURINE BASES UTILIZING THE MITSUNOBU REACTION. Nucleosides and Nucleotides 1996, 15, 1771. <https://doi.org/10.1080/07328319608002731>
• Bridges C G, Taylor D L, Ahmed P S, Brennan T M, Hornsperger J M, Navé J F, Casara P, Tyms A S: MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection. Antimicrob Agents Chemother 1996, 40, 1072. <https://doi.org/10.1128/AAC.40.5.1072>
• Cherrington J M, Mulato A S, Fuller M D, Chen M S: Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro. Antimicrob Agents Chemother 1996, 40, 2212. <https://doi.org/10.1128/AAC.40.9.2212>
• Mulato A. S., Cherrington J. M., Chen M. S.: Anti-HCMV Activity of Cidofovir in Combination with Antiviral Compounds and Immunosuppressive Agents: In-Vitro Analyses. Antivir Chem Chemother 1996, 7, 203. <https://doi.org/10.1177/095632029600700405>
• Taylor D.L., Ahmed S.P., Brennan T.M., Navé J.-F., Casara P., Tyms A.S.: Anti-HIV Activity of MDL 74968, a Novel Acyclonucleotide Derivative of Guanine: Drug Resistance and Drug Combination Effects in Vitro. Antivir Chem Chemother 1996, 7, 253. <https://doi.org/10.1177/095632029600700505>
• Cundy Kenneth C., Lynch Geoffrey, Shaw Jeng-Pyng, Hitchcock Michael J. M., Lee William A.: Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits. Current Eye Research 1996, 15, 569. <https://doi.org/10.3109/02713689609000768>
• Balzarini J., Verstuyf A., Hatse S., Goebels J., Sobis H., Vandeputte M., De Clercq E.: The human immunodeficiency virus(HIV) inhibitor 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) is a strong inducer of differentiation of several tumor cell lines. Intl Journal of Cancer 1995, 61, 130. <https://doi.org/10.1002/ijc.2910610122>
• Smith Jeffrey L., Allen Simon J.W., Cherrington Julie M.: A rapid antiviral in situ enzyme-linked immunosorbent assay for feline immunodeficiency virus. J Virol Met 1995, 54, 29. <https://doi.org/10.1016/0166-0934(95)00023-N>
• Navé Jean-François, Taylor Debra, Tyms Stan, Kenny Michael, Eggenspiller Anne, Eschbach Anne, Dulworth Jacqueline, Brennan Tara, Piriou François, Halazy Serge: Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine. Antivir Res 1995, 27, 301. <https://doi.org/10.1016/0166-3542(95)00023-F>
• Cihlár T, Rosenberg I, Votruba I, Holý A: Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated. Antimicrob Agents Chemother 1995, 39, 117. <https://doi.org/10.1128/AAC.39.1.117>
• Cherrington J. M., Allen S. J. W., Bischofberger N., Chen M. S.: Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ. Antivir Chem Chemother 1995, 6, 217. <https://doi.org/10.1177/095632029500600403>
• Naesens L., Balzarini J., De Clercq E.: Therapeutic potential of PMEA as an antiviral drug. Reviews in Medical Virology 1994, 4, 147. <https://doi.org/10.1002/rmv.1980040302>
• Caliò Raffaele, Villani Nicoletta, Balestra Emanuela, Sesa Francesca, Holy' Antonin, Balzarini Jan, De Clercq Erik, Perno Carlo Federico, Del Gobbo Vera: Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. Antivir Res 1994, 23, 77. <https://doi.org/10.1016/0166-3542(94)90034-5>
• Villani Nicoletta, Caliò Raffaele, Balestra Emanuela, Balzarini Jan, De Clercq Erik, Fabrizi Emanuele, Perno Carlo-Federico, Del Gobbo Vera: 9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system. Antiviral Research 1994, 25, 81. <https://doi.org/10.1016/0166-3542(94)90098-1>
• Franchetti P., Sheikha G. Abu, Cappellacci L., Messini L., Grifantini M., Loi A. G., Montis A. De, Spiga M. G., Colla P. La: 8-Aza-analogues of PMEA and PMEG: Synthesis and In Vitro Anti-HIV Activity. Nucleosides and Nucleotides 1994, 13, 1707. <https://doi.org/10.1080/15257779408009475>
• Hartmann K., Balzarini J., Higgins J., De Clercq E., Pedersen N. C.: In vitro Activity of Acyclic Nucleoside Phosphonate Derivatives against Feline Immunodeficiency Virus in Crandell Feline Kidney Cells and Feline Peripheral Blood Lymphocytes. Antivir Chem Chemother 1994, 5, 13. <https://doi.org/10.1177/095632029400500103>
• Yokota T., Konno K., Shigeta S., Holy A., Balzarini J., De Clercq E.: Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in HB611 Cells. Antivir Chem Chemother 1994, 5, 57. <https://doi.org/10.1177/095632029400500201>
• Naesens Lieve, Neyts Johan, Balzarini Jan, Holy Antonin, Rosenberg Ivan, De Clercq Erik: Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice. Journal of Medical Virology 1993, 39, 167. <https://doi.org/10.1002/jmv.1890390215>
• Neyts J., Stals F., Bruggeman C., De Clercq E.: Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo. Eur. J. Clin. Microbiol. Infect. Dis. 1993, 12, 437. <https://doi.org/10.1007/BF01967438>
• Heijtink R.A., De Wilde G.A., Kruining J., Berk L., Balzarini J., De Clercq E., Holy A., Schalm S.W.: Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) on human and duck hepatitis B virus infection. Antivir Res 1993, 21, 141. <https://doi.org/10.1016/0166-3542(93)90050-S>
• Puech Frédéric, Gosselin Gilles, Lefebvre Isabelle, Pompon Alain, Aubertin Anne-Marie, Kirn André, Imbach Jean-Louis: Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process. Antivir Res 1993, 22, 155. <https://doi.org/10.1016/0166-3542(93)90093-X>
• Villemin Didier, Thibault-Starzyk Frédéric: Synthesis of a New Sulfur Analog of PMEA. Synth Common 1993, 23, 1053. <https://doi.org/10.1080/00397919308018581>
• Thormar H, Balzarini J, Holy A, Jindrich J, Rosenberg I, Debyser Z, Desmyter J, De Clercq E: Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs. Antimicrob Agents Chemother 1993, 37, 2540. <https://doi.org/10.1128/AAC.37.12.2540>
• Balzarini J, Holy A, Jindrich J, Naesens L, Snoeck R, Schols D, De Clercq E: Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrob Agents Chemother 1993, 37, 332. <https://doi.org/10.1128/AAC.37.2.332>
• Sigel Helmut, Chen Dong, Corfù Nicolas A., Gregáň Fridrich, Holý Antonin, Strakšá Milan: Metal‐ion‐coordinating properties of various phosphonate derivatives, including 9−[2−(phosphonylmethoxy)ethyl]adenine (PMEA) – an adenosine monophosphate (AMP) analogue with antiviral properties. Helvetica Chimica Acta 1992, 75, 2634. <https://doi.org/10.1002/hlca.19920750817>
• Merta Aleš, Votruba Ivan, Jindřich Jindřich, Holý Antonín, Cihlář Tomás̆, Rosenberg Ivan, Otmar Miroslav, Herve Tchaou Y.: Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells. Biochemical Pharmacology 1992, 44, 2067. <https://doi.org/10.1016/0006-2952(92)90110-5>
• Hartmann K., Donath A., Beer B., Egberink H.F., Horzinek M.C., Lutz H., Hoffmann-Fezer G., Thum I., Thefeld S.: Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms. Vet Immunol Immunpathol 1992, 35, 167. <https://doi.org/10.1016/0165-2427(92)90129-E>
• Starrett John E., Tortolani David R., Hitchcock Michael J.M., Martin John C., Mansuri Muzammil M.: Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine. Antivir Res 1992, 19, 267. <https://doi.org/10.1016/0166-3542(92)90084-I>
• Balzarini Jan, Perno Carlo-Federico, Schols D., De Clercq Erik: Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes. Biochemical and Biophysical Research Communications 1991, 178, 329. <https://doi.org/10.1016/0006-291X(91)91818-W>
• Wolff-Kugel D., Halazy S.: Synthesis of new carbocyclic phosphonate analogs of dideoxypurine nucleotides. Tetrahetron Lett 1991, 32, 6341. <https://doi.org/10.1016/0040-4039(91)80164-2>
• Soike K.F., Huang J.-L., Zhang J.-Y., Bohm R., Hitchcock M.J.M., Martin J.C.: Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys. Antivir Res 1991, 16, 17. <https://doi.org/10.1016/0166-3542(91)90055-V>
• Naesens Lieve, Balzarini Jan, De Clercq Erik: Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo. Antivir Res 1991, 16, 53. <https://doi.org/10.1016/0166-3542(91)90058-Y>
• Del Gobbo Vera, Foli Andrea, Balzarini Jan, De Clercq Erik, Balestra Emanuela, Villani Nicoletta, Marini Stefano, Perno Carlo Federico, Calio Raffaele: Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models. Antivir Res 1991, 16, 65. <https://doi.org/10.1016/0166-3542(91)90059-Z>
• Hoover Edward A., Ebner James P., Zeidner Nordin S., Mullins James I.: Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonyl-methoxyethyl)adenine (PMEA). Antivir Res 1991, 16, 77. <https://doi.org/10.1016/0166-3542(91)90060-5>
• Maudgal P.C., De Clercq E.: Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK− HSV-1 keratitis in rabbits. Antivir Res 1991, 16, 93. <https://doi.org/10.1016/0166-3542(91)90061-U>
• De Castro Laura M., Kern Earl R., De Clercq Erik, Ghaffar Abdul, Mayer Eugene P., Vogt Peggy E., Gangemi J.David: Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. Antivir Res 1991, 16, 101. <https://doi.org/10.1016/0166-3542(91)90062-V>
• Foster S A, Cerny J, Cheng Y C: Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. Journal of Biological Chemistry 1991, 266, 238. <https://doi.org/10.1016/S0021-9258(18)52426-1>
• Schwalbe Carl H., Thomson William, Freeman Sally: Structural studies on bio-active molecules. Part 17. Crystal structure of 9-(2′-phosphonomethoxyethyl)adenine (PMEA). J. Chem. Soc., Perkin Trans. 1 1991, 1348. <https://doi.org/10.1039/P19910001348>
• Balzarini Jan, Sobis Halina, Naesens Lieve, Vandeputte Michel, De Clercq Erik: Inhibitory effects of 9‐(2‐Phosphonylmethoxyethyl)adenine and 3′‐azido‐2′,3′‐dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus. Intl Journal of Cancer 1990, 45, 486. <https://doi.org/10.1002/ijc.2910450319>
• Balzarini Jan, Naesens Lieve, Clercq Erik De: Anti‐retrovirus activity of 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered. Intl Journal of Cancer 1990, 46, 337. <https://doi.org/10.1002/ijc.2910460233>
• Midoux Patrick, Negre Eric, Roche Annie-Claude, Mayer Roger, Monsigny Michel, Balzarini Jan, De Clercq Erik, Mayer Eugene, Ghaffar Abdul, Gangemi J.David: Drug targeting: Anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine. Biochemical and Biophysical Research Communications 1990, 167, 1044. <https://doi.org/10.1016/0006-291X(90)90628-Z>
• Votruba Ivan, Trávníček Miloslav, Rosenberg Ivan, Otmar Miroslav, Merta Ales, Hřebabecký Hubert, Holý Antonín: Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues. Antivir Res 1990, 13, 287. <https://doi.org/10.1016/0166-3542(90)90013-W>
• Holý A., Votruba I., Merta A., Černý J., Veselý J., Vlach J., Šedivá K., Rosenberg I., Otmar M., Hřebabecký H.: Acyclic nucleotide analogues: Synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antivir Res 1990, 13, 295. <https://doi.org/10.1016/0166-3542(90)90014-X>
• Vonka Vladimír, Anisimová Emma, Černý Jaroslav, Holy Antonín, Rosenberg Ivan, Votruba Ivan: Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant. Antivir Res 1990, 14, 117. <https://doi.org/10.1016/0166-3542(90)90049-D>
• Merta Ales̆, Votruba Ivan, Rosenberg Ivan, Otmar Miroslav, Hr̆ebabecký Hubert, Bernaerts Ria, Holý Antonín: Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues. Antivir Res 1990, 13, 209. <https://doi.org/10.1016/0166-3542(90)90066-G>
• c̆erný Jaroslav, Votruba Ivan, Vonka Vladimír, Rosenberg Ivan, Otmar Miroslav, Holý Antonín: Phosphonylmethyl ethers of acyclic nucleoside analogues: Inhibitors of HSV-1 induced ribonucleotide reductase. Antivir Res 1990, 13, 253. <https://doi.org/10.1016/0166-3542(90)90070-N>
• BRONSON JOANNE J., HO HSU‐TSO, BOECK HILDE DE, WOODS KATHLEEN, GHAZZOULI ISMAIL, MARTIN JOHN C., HITCHCOCK MICHAEL J. M.: Biochemical Pharmacology of Acyclic Nucleotide Analogues. Annals of the New York Academy of Sciences 1990, 616, 398. <https://doi.org/10.1111/j.1749-6632.1990.tb17859.x>
• Field H J, Awan A R: Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease. Antimicrob Agents Chemother 1990, 34, 709. <https://doi.org/10.1128/AAC.34.5.709>
• Naesens L., Balzarini J., Rosenberg I., Holý A., Clercq E.: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-moloney murine sarcoma virus activity in vivo. Eur. J. Clin. Microbiol. Infect. Dis. 1989, 8, 1043. <https://doi.org/10.1007/BF01975167>
• Gangemi J D, Cozens R M, De Clercq E, Balzarini J, Hochkeppel H K: 9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections. Antimicrob Agents Chemother 1989, 33, 1864. <https://doi.org/10.1128/AAC.33.11.1864>
• De Clercq E, Holý A, Rosenberg I: Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrob Agents Chemother 1989, 33, 185. <https://doi.org/10.1128/AAC.33.2.185>
• HOLY A., ROSENBERG I.: ChemInform Abstract: Acyclic Nucleotide Analogues. Part 3. Synthesis of 9‐(2‐Phosphonylmethoxyethyl)adenine and Related Compounds. ChemInform 1988, 19. <https://doi.org/10.1002/chin.198811350>
• Holy Antonin, Rosenberg Ivan, Dvofakova Hana, Declercq Erik: Synthesis and Evaluation of Acyclic Nucleotide Analogs. Nucleosides and Nucleotides 1988, 7, 667. <https://doi.org/10.1080/07328318808056305>
• Snoeck R, Sakuma T, De Clercq E, Rosenberg I, Holy A: (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother 1988, 32, 1839. <https://doi.org/10.1128/AAC.32.12.1839>
• Pauwels R, Balzarini J, Schols D, Baba M, Desmyter J, Rosenberg I, Holy A, De Clercq E: Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrob Agents Chemother 1988, 32, 1025. <https://doi.org/10.1128/AAC.32.7.1025>