Collect. Czech. Chem. Commun. 1986, 51, 2034-2049

Heterocyclic ethers derived from 6,11-dihydrodibenzo[b,e]thiepin-11-ols and 4,9-dihydrothieno[2,3-c]-2-benzothiepin-4-ol; A new series of potential antidepressants and antihistamine agents

Zdeněk Polívka, Jan Metyš and Miroslav Protiva

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3


Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and methanesulfonates of 6,11-dihydrodibenzo[b,e]thiepin-11-ol (I), its 2-methyl derivative II and 4,9-dihydrothieno[2,3-c]-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1-methylperhydroazepin-4-ol (XIX), and tropine gave the ethers V-X. Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and antihistamine activities of various degree. The most active compounds were the ethers V and VI.